References

References

  1. International Cartilage Repair Society. About cartilage. www.cartilage.org/index.php?pid=22&lang=1. Accessed July 16, 2015.
  2. Center for Disease Control and Prevention. Arthritis: meeting the challenge of living well. www.cdc.gov/chronicdisease/resources/publications/aag/pdf/2014/arthritis-aag-2014.pdf. Published 2014. Accessed July 16, 2015.
  3. Parmet S, Lynm C, Glass RM. Osteoarthritis of the knee. JAMA. 2003;289(8):1068.
  4. Messsier SP, Gutekunst DJ, Davis C, DeVita P. Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum. 2005;52(7):2026-2032.
  5. Ding C, Cicuttini F, Blizzard L, Jones G. Genetic mechanisms of knee osteoarthritis: a population-based longitudinal study. Arthritis Res Ther. 2006;8(1):1-8.
  6. American College of Rheumatology. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum. 2000;43(9):1905­1915.
  7. Arthritis Foundation. 25 Treatments for arthritis hip and knee pain. Guidelines recommend combining drugs with non-medicinal remedies. www.arthritis.org/living-with-arthritis/pain-management/tips/25-treatments-for-hip-knee-oa.php. Accessed July 16, 2015.
  8. Arthritis Foundation. The right amount of vitamin C. www.arthritis.org/living-with-arthritis/treatments/natural/vitamins-minerals/vitamin-c-amount.php. Accessed July 16, 2015.
  9. Mayo Clinic. Arthritis. www.mayoclinic.org/diseases-conditions/arthritis/in-depth/arthritis/art-20046440?pg=1&p=1. Published July 23, 2014. Accessed July 16, 2015.
  10. Mayo Clinic. Knee replacement. www.mayoclinic.org/tests-procedures/knee-replacement/basics/definition/prc-20019202?p=1. Published October 30, 2012. Accessed July 16, 2015.
  11. Balazs EA, Denlinger JL. Viscosupplementation: a new concept in the treatment of osteoarthritis. J Rheumatol Suppl. 1993;39:3­ 9.
  12. Strand V, Conaghan PG, Lohmander LS, et al. An integrated analysis of five double-blind, randomized controlled trials evaluating the safety and efficacy of a hyaluronan product for intra-articular injection in osteoarthritis of the knee. Osteoarthritis Cartilage. 2006;14(9):859-866.
  13. SUPARTZ FX [package insert]. Durham, NC: Bioventus LLC; 2015.
  14. Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162(1):46-54.
  15. Day R, Brooks P, Conaghan PG, Petersen M, Multicenter Trial Group. A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee. J Rheumatol. 2004;31(4):775-782.
  16. Sun SF, Hsu CW, Hwang CW, et al. Hyaluronate improves pain, physical function and balance in the geriatric osteoarthritic knee: a 6-month follow-up study using clinical tests. Osteoarthritis Cartilage. 2006;14(7):696-701.
  17. Altman R, Lim S, Dasa V. Intra-articular hyaluronic acid delays total knee replacement (TKR) in patients with knee OA: evidence from a large U.S. health claims database. Osteoarthritis Cartilage. 2015;23(2):A403.
  18. Data on File. Bioventus LLC, Durham, NC. RPT-000310; Regulatory file 29000.142. SUPARTZ FX file of prospective clinical studies.
  19. Data on File. Bioventus LLC, Durham, NC. RPT-000309; Regulatory file 12000.29. Based on Seikagaku Corporation Annual Report 2013.
  20. Supartz FX [patient information]. Durham, NC: Bioventus LLC; 2015.
  21. Data on File. Bioventus LLC, Durham, NC. RPT-000308; Regulatory file 12000.16 IMS Health Data. Global sales 2004 – 2009.
  22. Hinton R, Moody RL, Davis AW, Thomas SF. Osteoarthritis: Diagnosis and Therapeutic Considerations. Am Fam Physician. 2002;65(5):841-849.
  23. Tang T, Muneta T, Ju Y-J, et al. Serum keratin sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injection. Arthritis Res Ther. 2008;10:R13. DOI:10.1186/ar2363.
  24. Takahashi K, Hashimoto S, Kubo T, et al. Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis. J Rheumatol. 2000;27(7):1713-1720.
  25. Asari A, Miyauchi S, Matsuzaka S, et al. Molecular weight-dependent effects of hyaluronate on the arthritic synovium. Arch Histol Cytol. 1998;61(2):125-135.
  26. Fukuda K, Hidekazu D, Masafumi T, et al. Hyaluronic acid increases proteoglycan synthesis in bovine articular cartilage in the presence of interleukin-1. J Pharm Exp Ther. 1996;277(3):1672-1675.
  27. Mitsui Y, Gotoh M, Nakama K, et al. Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E2 production via CD44 in interleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease. J Orthop Res. 2008;26:1032-1037.
  28. Wang C-T, Lin Y-T, Chiang B-L, Lin Y-H, Hou S-M. High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. Osteoarthr Cartilage. 2006;14:1237-1247.
  29. Waddell DD, Kolomytkin OV, Dunn S, Marino AA. Hyaluronan suppresses IL-1β-induced metalloproteinase activity from synovial tissue. Clin Orthop Relat Res. 2007;465:241-248.
  30. Julovi SM, Yasuda T, Shimizu M, Hiramitsu T, Nakamura T. Inhibition of interleukin-1β-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis Rheum. 2004;50(2):516-525.
  31. Ohshima Y, Yokota S, Kasama K, Ono H. Comparative studies of levels of proteins, bacterial endotoxins and nucleic acids in hyaluronan preparations used to treat ostheoarthritis of the knee—could residual proteins and bacterial endotoxins relate to complications? Jpn Pharmacol Ther. 2004; 32(10):655:662.
  32. Synvisc [package insert]. Ridgefield, NJ: Genzyme Corporation; 2010.
  33. Hyalgan [package insert]. Abano Terne, Italy: Fidia Farmaceuticals, S.p.A. 2011.
  34. Altman R, Moskowitz R., and the Hyagan Study Group. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. J Rheumatol. 1998;25(11):2203-2212.
  35. Euflexxa [package insert]. Parsippany, NJ: Ferring Pharmaceuticals Inc.; 2011.
  36. Orthovisc [package insert]. Raynham, MA: DePuy Mitek, Inc.; 2006.
  37. Karlsson J, Sjögren LS, Lohmander LS. Comparison of two hyaluronan drugs and placebo in patients with knee osteoarthritis. A controlled, randomized, double-blind, parallel-design multicentre study. Rheumatology (Oxford). 2002;41(11):1240-1248.
  38. Marks R, Penton L. Are foot orthotics efficacious for treating painful medial compartment knee osteoarthritis? A review of the literature. Int J Clin Pract. 2004;58:49-57.
  39. Mayo Clinic. Osteoarthritis. Treatment and drugs. http://www.mayoclinic.org/diseases-conditions/osteoarthritis/diagnosis-treatment/treatment/txc-20198275. Accessed November 14, 2012.
  40. Shimizu M, Higuchi H, Takagishi K, et al. Clinical and biochemical characteristics after intra-articular injection for the treatment of osteoarthritis of the knee: prospective randomized study of sodium hyaluronate and corticosteroid. J Orthop Sci. 2010;15(1):51-56.
  41. Synvisc-One [package insert]. Ridgefield, NJ: Genzyme Corporation; 2010.
  42. Monovisc [package insert]. Raynham, MA: DePuy Mitek, Inc.; 2013.
  43. Gel-One [package insert]. Warsaw, IN: Zimmer; 2011.
  44. Arthritis Foundation. What is arthritis? http://www.arthritis.org/about-arthritis/understanding-arthritis/what-is-arthritis.php. Accessed August 8, 2015.
  45. National Institute of Arthritis, Musculoskeletal and Skin Diseases. Handout on health: Osteoarthritis key words. http://www.niams.nih.gov/Health_Info/Osteoarthritis/#13. Accessed August 10, 2015.
  46. Arthritis Foundation. What is osteoarthritis? http://www.arthritis.org/about-arthritis/types/osteoarthritis/what-is-osteoarthritis.php. Accessed August 5, 2015.
  47. Arthritis Foundation. Osteoarthritis Prevention: What You Can Do. http://www.arthritis.org/about-arthritis/types/osteoarthritis/articles/oa-prevention.php. Accessed August 5, 2015.
  48. Arthritis Foundation. Osteoarthritis causes. http://www.arthritis.org/about-arthritis/types/osteoarthritis/causes.php. Accessed August 5, 2015.
  49. Arthritis Foundation. Osteoarthritis treatment. http://www.arthritis.org/about-arthritis/types/osteoarthritis/treatment.php. Accessed August 5, 2015.
  50. Centers for Disease Control. Fast stats: Inpatient surgery. http://www.cdc.gov/nchs/fastats/inpatient-surgery.htm. Accessed August 6, 2015.
  51. Centers for Disease Control. National Hospital Discharge Survey: 2010 table, Procedures by selected patient characteristics – Number by procedure category and age. http://www.cdc.gov/nchs/data/nhds/4procedures/2010pro4_numberprocedureage.pdf. Accessed August 6, 2015.
  52. Beswick AD, Wylde V, Gooberman-Hill R, Blom A, Dieppe P. What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systemic review of prospective studies in unselected patients. BMJ Open. 2012;2:1-12.
  53. Dreinhofer KE, Dieppe P, Sturmer T, et al. Indications for total hip replacement: comparison of assessments of orthopaedic surgeons and referring physicians. Ann Rheum Dis. 2006;65:1346e50.
  54. American Association of Hip and Knee Surgeons. Total knee replacement. http://www.aahks.org/care-for-hips-and-knees/do-i-need-a-joint-replacement/total-knee-replacement/. Accessed August 12, 2015.
  55. Arthritis Foundation. Knee replacement and revision surgeries on the rise. http://www.arthritis.org/living-with-arthritis/treatments/joint-surgery/types/knee/knee-replacement-younger-patients.php. Accessed August 12, 2015.
  56. Arthritis Foundation. Eat right for your type of arthritis. http://www.arthritis.org/living-with-arthritis/arthritis-diet/anti-inflammatory/eat-to-beat-inflammation.php. Accessed August 12, 2015.
  57. McAlindon T, Jacques P, Zhang Y, Hannan M, Aliabad P, Weissman B, et al. Do antioxidant micronutrients protect against the development of knee osteoarthritis? Arthritis Rheum 1996;39(4):648.
  58. Misra D, Booth S, Tolsytkh I, Felson D, Nevitt M, Lewis C, et al. Vitamin K deficiency is associated with incident knee osteoarthritis. Am J Med. 2013; 126(3):243.
  59. North CJ, Venter CS, Jerlin JC. The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease. Eur J Clin Nutr. 2009;63:921.
  60. Sturmer T, Brenner H, Koenig W, Gunther KP. Severity and extent of osteoarthritis and low grade systemic inflammation as assessed by high sensitivity C-reactive protein. Ann Rheum Dis. 2004;63:200.
  61. Ameye L, Chee W. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther. 2006;8:R127.
  62. Lu B, Driban J, Duryea J, McAlindon T, Lapane K, Eaton C. Milk consumption and progression of the medial tibiofemoral knee osteoarthritis: data from the osteoarthritis initiative. Arthritis Care Res. 2014;66(6):802.
  63. Doria E, Campion B, Sparvoli F, Tava A, Nielsen E. Anti-nutrient components and metabolites with health implications in seeds of 10 common bean (Phaseolus vulgaris L. and Phaseolus lunatus L.) landraces cultivated in sourthern Italy. J Food Compost Anal. 2012;26:72.
  64. Arthritis Foundation. 12 Best foods for Arthritis: Nosh on Nuts. http://www.arthritis.org/living-with-arthritis/arthritis-diet/best-foods-for-arthritis/best-foods-for-arthritis-13.php. Accessed August 11. 2015.
  65. Musumeci G, Trovato FM, Pichler K, Weinberg AM, Loreto C, Castrogiovanni, P. Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression. J Nutr Biochem. 2013;24:2064.
  66. Arthritis Foundation. The Ultimate Arthritis Diet. http://www.arthritis.org/living-with-arthritis/arthritis-diet/anti-inflammatory/the-arthritis-diet.php. Accessed August 11, 2015.
  67. Hoosmand S, Soung DY, Lucas EA, Madihally SV, Levenson C, Arjmandi B. Genistein reduces the production of proinflammatory molecules in human chondrocytes. J Nutr Biochem. 2007;18:609.
  68. Arjmandi BH, Khalil DA, Lucas EA, Smith BJ, Sinichi N, Hodges SB, et al. Soy protein may alleviate osteoarthritis symptoms. Phytomedicine. 2004;11:567.
  69. Leong D, Choudhury M, Hanstein R, Hirsh D, Kim SJ, Majeska R, et al. Green tea polyphenol treatment is condroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model. Arthritis Res Ther. 2014;16:508.
  70. Steenvoorden MMC, Huizinga, TWJ, Verzijl N, Bank R, Ronday HK, Luning, HAF, et al. Activation of receptor for advanced glycation end protducts in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes. Arthritis Rheum. 2006;54(1):253.
  71. Garg S, Syngle A, Vohra K. Efficacy and tolerability of advanced glycation end-products inhibitor in osteoarthritis. Clin J Pain. 2013;29(8):717.
  72. Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010;110(6):911.
  73. Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF. Obesity and Knee Osteoarthritis: The Framingham Study. Ann Intern Med. 1988:109(1):18-24.
  74. Thijssen E, van Caam A, van der Kraan. Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity induced osteoarthritis. Rheumatology. 2015;54(4):588-600.
  75. Batsis JA, Zbehlik AJ, Barre LK, Bynum JPW, Pidgeon D, et al. Impact of obesity on disability, function, and physical activity: data from the Osteoarthritis Initiative. Scand J Rheumatol. 2015;1-8.
  76. O’Neil CE, Zanovec M, Cho SS, Nicklas TA, et al. Whole grain and fiber consumption are associated with lower body weight measures in US adults: National Health and Nutrition Examination Survey. Nutr Res. 2010; 30(12):815-822.
  77. Wyatt HR, Grunwalkd GK, Mosca CL, Klem ML, Wing RR, Hill JO. Long-term weight loss and breakfast in subjects in the National Weight Control Registry. Obes Res. 2002;10(2):78-82.
  78. Ettinger WHJ, Burns R, Messier SP, et al. A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST). JAMA. 1997;277(1):25–31.
  79. Lee J, Chang RW, Ehrlich-Jones L, et al. Sedentary behavior and physical function: objective evidence from the Osteoarthritis Initiative. Arthritis Care Res. 2015;67(3):366-373.
  80. Henriksen M, Klokker L, Graven-Nielsen T, et al. Association of exercise therapy and reduction of pain sensitivity in patients with knee osteoarthritis: a randomized controlled trial. Arthritis Care Res. 2014;66(12):1836-1843.
  81. White DK, Tudor-Locke C, Zhang Y, et al. Daily walking and the risk of incident functional limitation in knee osteoarthritis: an observational study. Arthritis Care Res. 2014;66(9):1328-1336.
  82. Arthritis Foundation. 6 exercises for knee OA pain. http://www.arthritis.org/about-arthritis/types/osteoarthritis/articles/6-exercises-for-knee-oa-pain.php. Accessed August 10, 2015.
  83. Arthritis Foundation. Exercising with osteoarthritis. http://www.arthritis.org/living-with-arthritis/exercise/benefits/osteoarthritis-exercise.php. Accessed August 10, 2015.
  84. Roddy E, Zhang W, Doherty M. Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review. Ann Rheum Dis. 2005;64(4):544-548.
  85. Hunter DJ, Eckstein F. Exercise and osteoarthritis. J Anat. 2009;214:197-207.
  86. Vincent KR, Vincent HK. Resistance exercise for knee osteoarthritis. PMR. 2012;4(50):S45-S52.
  87. Felson DT. Weight and osteoarthritis. JRheumatol. 1995;43:7-9.
  88. Dillard JN. Use of complementary therapies to treat the pain of osteoarthritis. J Fam Pract 2011; 60(9 Suppl): S43-49.
  89. Arthritis Foundation. Arthritis & massage. http://www.arthritis.org/get-involved/healing-hands-for-arthritis/arthritis-and-massage.php. Accessed September 4, 2015.
  90. Arthritis Foundation. Types of massage. http://www.arthritis.org/living-with-arthritis/treatments/natural/other-therapies/massage/massage-types.php. Accessed on September 9, 2015.
  91. Arthritis Foundation. Benefits of massage. http://www.arthritis.org/living-with-arthritis/treatments/natural/other-therapies/massage/massage-benefits.php. Accessed September 9, 2015.
  92. Perlman AI, Sabina A, Williams A, Njike V, Katz DL. Massage therapy for osteoarthritis of the knee: A randomized controlled trial. Arch Intern Med. 2006;166(22):2533-2538.
  93. Shengelia R, Parker SJ, Ballin M, George T, Reid MC. Complementary therapies for osteoarthritis: Are they effective? Pain management nursing: official journal of the American Society of Pain Management Nurses. 2013;14(4):10.1016/j.pmn.2012.01.001.
  94. Rapaport MH, Schettler P, Bresee C. A Preliminary study of the effects of a single session of Swedish massage on hypothalamic–pituitary–adrenal and immune function in normal individuals. Journal of Alternative and Complementary Medicine. 2010;16(10):1079-1088.
  95. Perlman AI, Ali A, Njike VY, et al. Massage therapy for osteoarthritis of the knee: A randomized dose-finding trial. Thiem U, ed. PLoS ONE. 2012;7(2):e30248. doi:10.1371/journal.pone.0030248.
  96. Arthritis Foundation. Making Your massage appointment: What to know before you go. http://www.arthritis.org/living-with-arthritis/treatments/natural/other-therapies/massage/massage-appointment.php. Accessed on September 9, 2015.
  97. Arthritis Foundation. Self-massage relieves arthritis pain and stress. http://www.arthritis.org/living-with-arthritis/treatments/natural/other-therapies/massage/self-massage.php Accessed on September 9, 2015.
  98. Atkins DV, Eichler DA. The effects of self-massage on osteoarthritis of the knee: a randomized, controlled trial. International Journal of Therapeutic Massage & Bodywork. 2013;6(1):4-14.

SUPARTZ FX is indicated for treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen. You should not use SUPARTZ FX if you have infections or skin diseases at the injection site or allergies to poultry products. SUPARTZ FX is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site. Full prescribing information can be found here or by contacting customer service at
800-396-4325.