When you have knee osteoarthritis, the hyaluronic acid (HA) in the synovial fluid in your knee joint becomes diluted and breaks down—reducing its natural properties. (11) This is associated with increased inflammatory processes that can degrade the cartilage in your knee. (11)

This inflammation causes pain receptors to begin firing during normal movement. (11) The pain tends to cause knee osteoarthritis patients to limit movement which, in turn, limits to further deterioration of joint structures and synovial fluid quality because movement is required for normal synovial activity. This process can become a vicious cycle as the disease becomes progressively worse and quality of life is severely compromised for patients.

Breaking the vicious cycle

SUPARTZ FX treats knee osteoarthritis by providing temporary replacement for the diseased synovial fluid in your knee, which is an underlying cause of your pain. (11) Unlike oral analgesics or non-steroidal anti-inflammatory drugs (NSAIDs) that affect all parts of your body, SUPARTZ FX specifically targets the osteoarthritis in your knee. (13) In addition, treatment with hyaluronic acid such as SUPARTZ FX has the largest effect size for both pain and function as compared with other non-surgical treatment options.* (14)

*Based on effect sizes for pain at 3 months; statistically significant in comparison to acetaminophen, celecoxib, and naproxen. Based on effectiveness for function at 3 months; statistically significant in comparison to corticosteroids

SUPARTZ FX is indicated for treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen. You should not use SUPARTZ FX if you have infections or skin diseases at the injection site or allergies to poultry products. SUPARTZ FX is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site. Full prescribing information can be found here or by contacting customer service at