Questions Your Patients Might Ask

When you see your patients, they’ll have questions about osteoarthritis, their knee pain, and possible treatments. Here’s a sample of the questions they might ask and some information from Bioventus that can help you answer their questions:

  1. How do I know if I have osteoarthritis in my knee?
    You may have knee osteoarthritis if you experience one or more of the following common signs and symptoms:

    • Joint soreness after overuse or inactivity
    • Joint stiffness after resting or in the morning
    • Pain when moving your knee
    • Pain when using stairs or getting up from a chair
    • Pain that prevents you from exercising your leg
    • Grating or catching when moving your knee
    • Joint pain that feels worse in the evening after a day’s activity
    • Deterioration of coordination due to pain and stiffness
    • Weakened thigh muscles

    To help with your diagnosis and treatment, be sure to mention these signs and symptoms at each doctor’s appointment.

  2. How is osteoarthritis different from other kinds of arthritis?
    There are too many types of arthritis to list here (for a complete list, go to Osteoarthritis, or OA, refers to the breakdown, or degeneration, of cartilage and fluid that cushion and lubricate the bones
    in your joints. Osteoarthritis can occur in any joint, but osteoarthritis
    of the knee is the most common type, affecting more than 10 million
    Americans. (3)
  3. Why does osteoarthritis make my knee hurt?
    In knee osteoarthritis, the hyaluronic acid (HA) in the synovial fluid in your knee joint becomes diluted and breaks down—reducing its natural properties. (11) This is associated with increased inflammatory processes that can degrade the cartilage in your knee. (11) The inflammation causes pain receptors to begin firing during normal movement. (11) The pain tends to cause knee osteoarthritis patients to limit movement, which in turn leads to further deterioration of joint structures and synovial fluid quality because movement is required for normal synovial homeostasis.
  4. Are all knee injection therapies for osteoarthritis the same?
    No, there are different classes of injectable therapies that may be used to treat osteoarthritis in your knee. For example, steroids (such as cortisone) may help relieve pain and swelling temporarily. Opioids, such as morphine, are a class of drug with a very strong analgesic (pain-killing) effect. On the other hand, viscosupplements like SUPARTZ FX are designed to replace the diseased synovial fluid in your knee joint, which provides cushioning and lubrication.
  5. What is SUPARTZ FX?
    SUPARTZ FX, also called a viscosupplement, is a non-surgical, non-pharmacologic therapy for knee osteoarthritis. SUPARTZ FX can help relieve your knee pain, improve your mobility, and get you back to your normal activities.
  6. Why choose SUPARTZ FX?
    • Proven pain relief across multiple clinical studies (12,13,15,16)
    • As safe as saline in clinical studies (12,13,15,16)
    • More than 300 million SUPARTZ FX injections administered
      worldwide (19)
    • A flexible course of therapy, from 3 to 5 injections, so you only receive the number of shots that your doctor recommends
  7. Does treatment with SUPARTZ FX involve any other drugs or surgery?
    No additional drug or surgery is involved in treatment with SUPARTZ FX (other than a local anesthetic to numb your knee). You can schedule SUPARTZ FX treatments just as you would any other office visit. The whole procedure only takes a few minutes. Your doctor may advise you to avoid strenuous activities for a few days after your injections.
  8. How does SUPARTZ FX work?
    SUPARTZ FX treats knee osteoarthritis by temporarily replacing the diseased synovial fluid in your knee, which is an underlying cause of your pain. (11) Unlike oral analgesics or nonsteroidal anti-inflammatory drugs (NSAIDs) that affect all parts of your body, SUPARTZ FX specifically targets the osteoarthritis pain in your knee.
  9. Is SUPARTZ FX safe?
    In clinical studies, adverse events were no more common following treatment with SUPARTZ FX than comparable treatment with saline placebo. (12,13) In fact, more people discontinued treatment with saline placebo than those who received SUPARTZ FX therapy. (12) Pseudoseptic (acute inflammatory) reactions have NOT been reported in 20 prospective randomized controlled trials of SUPARTZ FX.* (18)
  10. How do I know if SUPARTZ FX is the right way to treat my knee?
    SUPARTZ FX may be the right treatment for you if:

    1. Your knee pain is due to osteoarthritis
    2. You are not getting adequate osteoarthritis knee pain relief from walking and/or physical therapy
    3. You are not getting adequate osteoarthritis knee pain relief from pain medications, including:
      1. Ibuprofen (e.g., Advil®)
      2. Acetaminophen (e.g., Tylenol®)
      3. Naproxen sodium (e.g., Aleve®)


  11. Is SUPARTZ FX covered by my insurance?
    SUPARTZ FX is covered by Medicare and many private insurance plans for the treatment of knee osteoarthritis pain. Private plan coverage may be determined prior to initiating SUPARTZ FX therapy by calling the plan directly.
  12. What if I don’t like needles—do the SUPARTZ FX injections hurt?
    Most patients experience little or no discomfort during the injection. (40) If you’re concerned about the injection, we can discuss ways to reduce any mild pain that may occur.
*Does not include current prescribing experience.
**All trademarks are the properties of their respective companies.

SUPARTZ FX is indicated for treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen. You should not use SUPARTZ FX if you have infections or skin diseases at the injection site or allergies to poultry products. SUPARTZ FX is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site. Full prescribing information can be found here or by contacting customer service at