SUPARTZ FX may be the right treatment for you if:

  1. Your knee pain is due to osteoarthritis
  2. You are not getting adequate osteoarthritis knee pain relief from walking and/or physical therapy
  3. You are not getting adequate osteoarthritis knee pain relief from pain medications, including:
    • Ibuprofen (e.g., Advil®)
    • Acetaminophen (e.g., Tylenol®)
    • Naproxen sodium (e.g., Aleve®)

If you meet these criteria, ask your doctor if SUPARTZ FX therapy is right for you!

Conversely, you should NOT receive SUPARTZ FX therapy if you have:

  • Allergies to products from birds, such as feathers, eggs, and poultry
  • Infections or skin diseases in the area in which the injection will be given
  • Had any previous allergic reactions to SUPARTZ FX therapy or similar material (hyaluronate products)

The safety and effectiveness of SUPARTZ FX have not been established in pregnant women, lactating women, and children.

In clinical trials reviewed by the FDA, the most common adverse events occurring in patients treated with SUPARTZ FX therapy were (13,20):

  • Joint pain with no evidence of inflammation
  • Joint pain with evidence of inflammation
  • Back pain
  • Pain (non-specific)
  • Injection site reaction (pain/swelling/effusion/redness/warmth)
  • Headache
  • Injection site pain

These adverse events also occurred at similar rates in patients treated with a saltwater placebo.

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SUPARTZ FX is indicated for treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen. You should not use SUPARTZ FX if you have infections or skin diseases at the injection site or allergies to poultry products. SUPARTZ FX is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site. Full prescribing information can be found here or by contacting customer service at